Tissue Characterization in Teeth Treated With a Regeneration Protocol
Status:
Completed
Trial end date:
2014-03-01
Target enrollment:
Participant gender:
Summary
The purpose of the investigators study is to characterize the composition of the hard and
soft tissues present in root canals of teeth previously diagnosed with necrotic pulps and
incomplete root formation and treated with a triple antibiotic regeneration protocol. The
investigators hypothesis is that treatment of teeth with necrotic pulps and immature apices
with triple antibiotic paste will stimulate continued root formation by the deposition of
dentin at the root apices. The primary outcome measure will be histological identification of
mineralized tissue and adherent cells in the apical third of these teeth.
Phase:
Early Phase 1
Details
Lead Sponsor:
The University of Texas Health Science Center at San Antonio
Treatments:
Anti-Bacterial Agents Antibiotics, Antitubercular Bacitracin Bacitracin zinc, neomycin sulfate, polymyxin B, drug combination Neomycin Polymyxin B