Tipifarnib, Radiation Therapy, and Temozolomide in Treating Patients With Newly Diagnosed Glioblastoma Multiforme
Status:
Completed
Trial end date:
2014-04-01
Target enrollment:
Participant gender:
Summary
This phase I trial studies the side effects and best dose of tipifarnib when given together
with radiation therapy and temozolomide in treating patients with newly diagnosed
glioblastoma multiforme. Tipifarnib may stop the growth of tumor cells by blocking some of
the enzymes needed for cell growth. Radiation therapy uses high energy x rays to kill tumor
cells. Drugs used in chemotherapy, such as temozolomide, work in different ways to stop the
growth of tumor cells, either by killing the cells, by stopping them from dividing, or by
stopping them from spreading. Giving tipifarnib together with radiation therapy and
temozolomide may be a better way to treat glioblastoma multiforme.