This research is being done to determine the safety and tolerability of timolol in the
treatment of acne and rosacea. The investigators will also look for specific biomolecular
changes in acne or rosacea skin when it is exposed to timolol.
Timolol is approved by the Food and Drug Administration (FDA) for the treatment of glaucoma.
In dermatology, it has been used as a treatment to decrease the size of vascular (blood
vessel) malformations in infant skin. Timolol is not approved for use in acne or rosacea and
its use in this study is investigational.
Many people with rosacea have telangiectasias which are small, red dilated blood vessels on
the skin. They also suffer from flushing and acne-like lesions. Better treatments than those
currently available are desired.
Acne vulgaris, or acne, is another chronic inflammatory and very common skin disease that
affects about 8 out of 10 young adults and adolescents. Signs of acne include papules and
blackheads that are often called primary lesions because they represent an active form of the
disease. There are also secondary lesions that can form later; they are known as acne scars