Timing of VTE Prophylaxis in TBI

• Status: Withdrawn
• Trial end date: 2019-08-12
• Target enrollment: 0
• Participant gender: All

Summary

This study compares the efficacy and complication rates of early (24 hours) versus late (72 hours) VTE prophylaxis administration to TBI patients. Patients in both treatment groups will be monitored for development of VTE as well as complications from bleeding after commencement of VTE prophylaxis.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Loyola University
• Treatments: Calcium heparin; Enoxaparin; Enoxaparin sodium; Heparin

Criteria

Inclusion Criteria:

• Traumatic brain injury

• Intracranial hemorrhage on CT scan

Exclusion Criteria:

• Under the age of 18

• Pregnant

• Die within 24 hours of admission

• Hospital stay less than 5 days

• Contraindications to enoxaparin or heparin

• Coagulopathy at 24 hours post-injury defined as INR>1.6 aPTT>2x normal, or platelet counts<50k

• Known history of VTE