Time of Ventilation and Lung Function of Ventilated Patients Under Therapy With Dornase Alfa

• Status: Unknown status
• Trial end date: 2006-07-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine whether Inhalation of Recombinant Human Deoxyribonuclease Shortens Ventilation Time in Mechanically Ventilated Adults

• Phase: Phase 2/Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University Hospital Tuebingen
• Collaborator: Joachim Riethmueller, Dr. med.

Criteria

Inclusion Criteria:

• adult

• mechanical ventilation

• expected ventilation time 3 days or longer

• full therapy is possible

• expectet ventilation time not longer than 21 days

Exclusion Criteria:

• medicinal point of view: patient won´t survive the next 21 days

• concomitant pneumococcal disease (like tuberculosis, carcinoma)

• endotracheal bleeding

• pneumothorax with no relief (e.g. thoracic drainage)

• pregnancy

• breast feeding

• participation in another clinical trail

• mechanical ventilation since more than 48 hours

• mechanical ventilation on the basis of another reason than operation, trauma or pulmonary decompensation