Time-lapse Monitoring of Early Embryo Development After Ovarian Stimulation During Infertility Treatment
Status:
Terminated
Trial end date:
2015-01-01
Target enrollment:
Participant gender:
Summary
The number of children conceived by assisted reproductive technology is increasing in Nordic
countries as well as worldwide. An important factor of success in treatment of infertility is
a short "time to pregnancy" with impact on both economical aspects for the society and
medical and psychological aspects for the couple. During treatment, success relies on 1)
optimal stimulation of growth and maturation of multiple follicles by administration of
exogenous follicle stimulating hormone (FSH), and 2) selection of the fertilized egg / embryo
with the highest potential of implantation to be transferred to the mother. In the present
project stimulation of egg production by human urine derived FSH (Fostimon®) and recombinant
FSH (Puregon®) will be compared. To this end early embryo development and kinetics after
fertilization will be evaluated. The system to be used is time-lapse recording of embryo
morphology during the first days of embryo development by means of an embryoscope. Aim of
this study is to investigate if Puregon and urinary Fostimon have different effect on embryo
quality. The hypothesis of the study is that stimulation of egg production by these two types
of follicle stimulating hormone does not have the same effect on early embryo quality.