Tight Glycemic Control Increases Cardiac Stem Cells During Acute Myocardial Infarction
Status:
Completed
Trial end date:
2009-01-01
Target enrollment:
Participant gender:
Summary
Objectives. The investigators analysed the effects of tight glycemic control in regenerative
potential of the myocardium during acute myocardial infarction (AMI).
Background. A strict glycemic control after AMI improves the cardiac outcome. The role of
tight glycemic control in regenerative potential of the myocardium during acute myocardial
ischemia are still largely unknown.
Methods. Sixty-five patients with first AMI undergoing coronary bypass surgery were studied:
25 normoglycemic patients served as control group; hyperglycemic patients (glucose >140
mg/dl) were randomized to intensive glycemic control (IGC, n=20; glucose goal 80-140 mg/dl)
or conventional glycemic control (CGC, n=20; glucose goal180-200 mg/dl) for almost 3 days
before surgery, using insulin infusion followed by subcutaneous insulin treatment.
Echocardiographic parameters were investigated at admission and after treatment period.
During surgery, oxidative stress (nitrotyrosine, O2- production), apoptosis (Caspase-3) and
cardiac stem cells (CSCs) (c-kit, MDR1 and Sca-1 positive cells) were analysed in biopsy
specimens taken from the peri-infarcted area.
Phase:
Phase 4
Details
Lead Sponsor:
Second University of Naples University of Campania "Luigi Vanvitelli"