Our aim is to compare the safety and efficacy of 2 different empiric levothyroxine dose
adjustment recommendations to be made at the first confirmation of pregnancy in women with a
history of hypothyroidism. Subjects will be women with a prior diagnosis of hypothyroidism
who are taking thyroid hormone replacement and who are less than 8 weeks pregnant. Upon
confirmation of pregnancy, subjects will be randomized to increase their weekly thyroid
hormone dose by either 2 or 3 tablets (28 or 42%). Thyroid function will be evaluated every
two weeks in the first 20 weeks and then again at week 30 and post-partum. Primary endpoints
will be the proportion of women in each group who remain euthyroid throughout the first
trimester and throughout pregnancy.
Phase:
N/A
Details
Lead Sponsor:
Brigham and Women's Hospital
Collaborators:
Harvard Medical School Harvard Medical School (HMS and HSDM) Harvard University