The prevalence of obesity in Mexico is 35.4%, and it is considered a risk factor for the
development of diabetes, systemic arterial hypertension and dyslipidemia. Obesity due to the
increased distribution and growth of adipose tissue creates a pro-inflammatory state induced
by molecules secreted by the adipocytes themselves. Netrin-1 is a cell migration protein,
which directs the recruitment, migration and entrapment of macrophages in different tissues,
within adipose tissue the entrapment of macrophages induces the release of pro-inflammatory
cytokines, which increase the secretion of pro-inflammatory adipokines. It has been found in
high concentration in patients with obesity, insulin resistance and type 2 diabetes. Thymol
is a phytopharmaceutical derived from oregano oil that has shown powerful anti-inflammatory
and antioxidant effects through the stimulation of PPAR-gamma, adiponectin and inhibition of
the NF-κB pathway mediated by the JNK pathway, pathways in which netrin-1 is involved in
macrophage entrapment and recruitment.
Phase:
Phase 2
Details
Lead Sponsor:
Centro Universitario de Ciencias de la Salud, Mexico