ThrombElastoGraphic Haemostatic Status and Antiplatelet Therapy After Coronary Artery Bypass Graft Surgery

• Status: Unknown status
• Trial end date: 2014-09-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine whether adding clopidogrel to aspirin after coronary bypass operation (CABG) improves graft patency, in patients that have preoperatively increased platelet activity(hypercoagulable) and therefore greater risk of graft occlusion( thrombosis).

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Rigshospitalet, Denmark
• Treatments: Aspirin; Clopidogrel; Hemostatics; Ticlopidine

Criteria

Inclusion Criteria:

• Elective/subacute multivessel CABG

• Isolated CABG procedure, no concomitant surgery

• age > 18 years

• Able to give informed consent

Exclusion Criteria:

• Myocardial infarction <48h of surgery

• Prior CABG surgery within 1 month

• Cardiac Shock within 48h of surgery

• Atrial fibrillation

• Anticoagulation therapy with VKA

• ICH/TCI within 30 days

• Prior peptic ulcer· Platelet count < 150 E9

• Ongoing bleeding

• Known platelet disease

• Allergic to aspirin or clopidogrel

• Liver disease with elevated ALAT/ASAT> 1,5x normal

• Creatinine> 0,120mmol/l

• Contrast allergy

• Alcohol or narcotics abuse

• Pregnancy

• Not able to give informed consent

• Geographically not available for follow up