Overview

Three Different Doses of Neostigmine on the Reversal of Cisatracurium-induced Moderate Neuromuscular Blockade

Status:
Not yet recruiting

Trial end date:
2021-12-20

Target enrollment:

Participant gender:

Summary

The aim of the present study will be to evaluate by means of a prospective randomized clinical trial, the time required for the reversal of moderate neuromuscular blockade (NMB) (Train-of-four count = 3; TOFc 3) to Train-of-four ratio (TOFr) > 0.9 and TOFr = 1.0 after administration of different doses of neostigmine (30, 50 and 70 mcg/kg) in patients undergoing general anesthesia with propofol or sevoflurane. In addition, the probability of NMB reversal in less than 10 minutes or 15 minutes after neostigmine administration will be registered.

Phase:

Phase 4

Details

Lead Sponsor:

Pontificia Universidade Catolica de Sao Paulo

Treatments:

Anesthetics
Neostigmine
Sevoflurane