Three Alternative Drug Regimens for Malaria Seasonal Preventive Treatment in Senegal
Status:
Completed
Trial end date:
2007-12-01
Target enrollment:
Participant gender:
Summary
The purpose of this trial is to compare the acceptability, efficacy and safety of three
alternative drug regimens for use for seasonal Intermittent Preventive Treatment to prevent
malaria in children. Children aged 2 months to 5 years will be randomized to receive IPT with
one of three regimens during the transmission season: sulfadoxine-pyrimethamine (SP) plus
amodiaquine, show to be highly effective for IPT in a recent trial; SP plus piperaquine, used
for malaria prophylaxis in China for many years; or Duocotexcin (a combination of piperaquine
with an artemisinin).