This Study Include Asthma Chronic Obstructive Pulmonary Disease (COPD) Overlap Patients.Patients Were Vitamin D Deficient.Age Range 40-70 Years, Smokers.Patients Were Advised to Take Either Placebo or Vitamin D3.Lung Functions and Exercise Tolerance

• Status: Completed
• Trial end date: 2019-02-20
• Target enrollment: 0
• Participant gender: Male

Summary

Vitamin D3 supplementation doen not change lung functions and exercise tolerance in vitamin D3 deficient ACO patient was the null hypothesis of the research.

• Phase: Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
• Treatments: Cholecalciferol; Ergocalciferols; Vitamin D; Vitamins

Criteria

Inclusion Criteria:

• Pulmonologist diagnosed patient of ACO

• Vitamin D3 deficient : Serum 25(OH)D <30 ng/ml

• Age: 40-70 years

• Sex: Male

• Socioeconomic status: middle class

• Smoker

• Anthropometric status:

BMI=18.6-24.9 kg mid upper arm circumference>25.1 cm waist-hip ratio<0.89

• Serum parathormone: 10-65 pg/ml

• Serum Ca2+: 8.5-10.5 mg/dl

• Serum PO43: 2.3-4.7 mg/dl

• Serum alkaline phosphatase: 30-120 U/L

• SGPT: <50 U/L

• Serum creatinine: 0.7-1.3 mg/dl

• Fasting Blood Sugar (FBS): 3.5-6.1 mmol/L

• Serum HbA1c: 4.5-6.3 %

• Serum cholesterol: <200 mg/dl

• Serum HDL: >40 mg/dl,

• Serum LDL: <130 mg/dl

• Serum TG: <150 mg/dl

Exclusion Criteria:

• With history of:

• any other pulmonary diseases, as, chronic obstructive pulmonary disease bronchial asthma respiratory tract infection bronchiectasis pleural effusion tuberculosis interstitial lung disease pneumonectomy or pulmonary lobectomy

• any cardiac disease, like - unstable angina pectoris congestive heart failure myocardial infarction cardiac arrhythmia

• systemic hypertension

• any liver disease

• any malignancy

• use of any drugs known to affect vitamin D metabolism within 1 month prior to study, as, antiepileptics (Phenytoin, Carbamazepine) antibiotics (Clotrimazole, Rifampicin) antihypertensives (Nifedipine, Spironolactone) antiretroviral drugs (Ritonavir, Saquinavir) endocrine drugs (Cyproterone acetate) glucocorticoids bisphosphonate calcium supplement

• With biochemical evidence of diabetes mellitus renal insufficiency