Thiamine as a Metabolic Resuscitator After Cardiac Arrest

• Status: Recruiting
• Trial end date: 2023-02-01
• Target enrollment: 0
• Participant gender: All

Summary

This is a randomized, double-blind, placebo controlled study to investigate the effect of intravenous thiamine (vitamin B1) on lactate, cellular oxygen consumption, global oxygen consumption and biomarkers of neurologic injury after out-of-hospital cardiac arrest (OHCA). .

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Michael Donnino
• Collaborator: National Heart, Lung, and Blood Institute (NHLBI)
• Treatments: Thiamine; Vitamins

Criteria

Inclusion Criteria:

• Adult patient (age ≥ 18 years)

• Cardiac arrest occurring with sustained (> 20 minutes) return of spontaneous circulation (ROSC)

• Within 4.5 hours of cardiac arrest event

• Lactate >/=3

Exclusion Criteria:

• Clinical indication for thiamine administration (alcoholism, known or highly suspected deficiency) or treatment with thiamine beyond the amount found in a standard multivitamin within the last 10 days

• Traumatic etiology of arrest

• Comfort measures only or anticipated withdrawal of support within 24 hours

• Protected populations (pregnant women, prisoners)

• Known allergy to thiamine