Objective: To evaluate the effects of perioperative glutamine supplemented total parenteral
nutrition support on nutritional status, immunologic function and intestinal permeability of
patients with chronic radiation intestinal injury.
Methods: The 40 patients with CRII were randomized into two groups, the standard TPN group
and glutamine-enriched TPN group. The patients were administered total parenteral nutrition
for at least four weeks (two weeks pre-operation and two weeks post-operation). The
nutritional status, immunologic function, plasma concentration of glutamine and intestinal
permeability were measured at 1 day, 1 week and 2 weeks pre-operation, 3 day, 1 week and 2
weeks post-operation. Nutrition status was determined the plasma concentrations of
hemoglobin, albumin, prealbumin, transferrin and triglyceride. Immunologic function were
measured by the percentages of CD4+T cells and CD8+T cells, the ratio of CD4 +T cells to
CD8+T cells ( CD4 +/CD8 +) was calculated， and serum IgA, IgM and IgG．The intestinal
permeability was detected by the urinal ratio of lactulose and mannitol.