Therapy for Infertile PCOS Patients Ovulating Under Clomiphene Citrate or Metformin
Status:
Withdrawn
Trial end date:
1969-12-31
Target enrollment:
Participant gender:
Summary
Several data demonstrated that both clomiphene citrate (CC) and metformin are two safe and
valid first-step options to induce ovulation in infertile anovulatory PCOS patients.
Notwithstanding a high percentage of patients ovulate under treatment, only ~40% and 60% of
subjects obtain a pregnancy after CC and metformin, respectively.
For these patients, controlled ovarian stimulation (COS) followed by intrauterine
insemination (IUI) could be the next therapeutic step before assisted reproductive techniques
since IUI improves significantly the fertility in couples with unexplained infertility.
Furthermore, to date it is not defined if COS should be obtained using the same ovulatory
agent (CC or metformin) or switching the treatment to gonadotropins.
In this view, the aim of the present study will be to evaluate the best management of
infertile PCOS patients ovulating after CC or metformin.