Therapy for Children With Advanced Stage High Risk Neuroblastoma
Status:
Completed
Trial end date:
2001-04-01
Target enrollment:
Participant gender:
Summary
This is a Phase II pilot study of chemotherapy and surgery for children with advanced stage
high-risk neuroblastoma utilizing topotecan during an upfront window and other active agents
during induction and intensification phases. The primary purpose is to estimate the response
rate to an upfront window of two cycles of intravenous topotecan. We hypothesize that the
topotecan window will be an effective therapy in terms of the response rate.