Therapeutic Effect of Tacrolimus on Primary Nephrotic Syndrome in Children
Status:
Completed
Trial end date:
2013-10-01
Target enrollment:
Participant gender:
Summary
To determine the efficacy of tacrolimus in the management of NS(nephrotic syndrome) , the
investigators designed this prospective study. The investigators will enroll 100 children
with NS(frequent relapse steroid dependent NS, steroid resistance NS) who will be treated
with tacrolimus (0.1-0.2 mg/kg/day in two divided doses over 12 h adjusted to a trough level
between 5 and 10 ng/ml) for 12 months in combination with low-dose steroids. Other therapies
will be included angiotensin-converting enzyme inhibitors, antihypertensive drugs,
multivitamins and lipid-lowering agents.
Follow-up is every second week for the first 4 weeks, then monthly. After initiation of
tacrolimus therapy, blood was drawn each visit to determine tacrolimus trough levels.