Allergic rhinitis and asthma are common respiratory diseases, which often coexist. The
prevalence of allergic rhinitis in subjects with asthma is up to 80%, and the prevalence of
asthma is 3-5 times greater in subjects with rhinitis than healthy controls. The mechanisms
of the allergen response in both diseases are parallel to each other, with similar mediator
and cellular responses to similar allergens. These observations have led to the suggestion
that both diseases are different expressions of one airway disease.We wish to evaluate the
effect of low dose theophylline in patients with asthma, given its effects as subtherapeutic
concentrations and the propensity to develop adverse events at higher doses.
Phase:
Phase 2
Details
Lead Sponsor:
University of East Anglia
Collaborator:
Clinical Research and Trials Unit (Norfolk & Norwich University Hospital, UK)