Overview

The Value of Molecular Residual Disease Monitoring Based on ctDNA in Borderline Resectable or Locally Advanced Pancreatic Cancer

Status:
Recruiting
Trial end date:
2030-02-01
Target enrollment:
0
Participant gender:
All
Summary
The goal of this clinical trial is to explore the value of molecular residual disease (MRD) monitoring based on ctDNA in borderline resectable or locally advanced pancreatic cancer. The main questions it aims to answer are: - prognostic value of baseline MRD; - the role of MRD dynamic changes after treatment in guiding treatment. Peripheral blood derived from participants will be obtained for MRD test before conversion therapy initiation and at the first imaging assessment after chemotherapy.
Phase:
N/A
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Peking Union Medical College Hospital
Criteria
Inclusion Criteria:

- patients with histologically confirmed borderline resectable or locally advanced
pancreatic cancer;

- conversion therapy was planned;

- both sexes, age ≥18 years old;

- ECOG performance status score ≤2;

- the expected survival time was ≥3 months.

Exclusion Criteria:

- a known diagnosis of pancreatic cancer other than ductal adenocarcinoma;

- treated with any systemic antitumor treatment before first-line chemotherapy onset;

- died or lost to follow-up within one month after the initiation of first-line
chemotherpay;

- combined with other primary malignances.