The Use of Venlafaxine in Reducing Pain in Primary Total Knee Replacement
Status:
Recruiting
Trial end date:
2022-05-04
Target enrollment:
Participant gender:
Summary
Patients experience pain after their knee replacement surgery - and some may continue to
experience persistent pain long after their knee replacement surgery. Traditional pain
management strategies reply on pain medication such as opioids for pain control. However,
these drugs do not work well for pain associated with movement or the the nerve pain
(tingling, electrical sensations) after surgery. In addition, opioids are associated with
significant side effects such as nausea, vomiting, respiratory depression, depression,
cognitive dysfunction and risk of persistent opioid use. Neuropathic pain medications, such
as venlafaxine are effective in managing nerve pain. Recent studies also support its
potential role in acute pain management. Here, we propose a prospective randomized clinical
trial 1) to evaluate the efficacy of Venlafaxine in reducing pain intensity and opioid
consumption at post-operative day 1 (POD1) and 1- week after surgery, and 2) to examine
whether the use of Venlafaxine will reduce the incidents of chronic postsurgical pain in TKA
patients at 3-month time point.