The Use of Sodium Bicarbonate in the Prevention of Contrast Induced Nephropathy
Status:
Terminated
Trial end date:
2009-01-01
Target enrollment:
Participant gender:
Summary
Preliminary studies have shown a benefit of sodium bicarbonate infusion in decreasing the
risk of contrast induced nephropathy with coronary angiography. The investigators plan to
randomize 478 patients (with serum creatinine 1.5 mg/dl or greater) undergoing coronary
angiography to intravenous isotonic saline or intravenous isotonic sodium bicarbonate
beginning one hour before the procedure and for four hours after. The primary endpoint is the
development of contrast nephropathy within 48-72 hours after the procedure. Patients with an
ejection fraction <30%, overt CHF, hypokalemia and alkalemia will be excluded.