The Use of Prostaglandin E1 in Head and Neck Microsurgery
Status:
Unknown status
Trial end date:
2010-07-01
Target enrollment:
Participant gender:
Summary
Prostaglandin E1 (PGE1 )has been shown to have vasodilatation and anti-thrombosis effects, so
it is used by some surgeons after microsurgery to keep the patency of the anastomosed small
vessels. However, PGE 1 may also causes some complications, like pleural effusion or deep
vein thrombosis. Therefore, it remains uncertain whether a routine use of PGE 1 after head
and neck microsurgery is justified. We aim to test the hypothesis that PGE 1 increases
postoperative vessel patency rate in patients undergoing head and neck microsurgery, with a
comparable complication rate as the control group.