The Use of Pentoxifylline and Vitamin E in the Treatment of Chronic Breast Pain
Status:
Terminated
Trial end date:
1969-12-31
Target enrollment:
Participant gender:
Summary
An estimated 20 - 45 % of women treated with breast conserving treatment experience chronic
pain in the treated breast. The aetiology of this is poorly understood. Some of these women
have signs of chronic radiation mastitis. There is no accepted treatment for this condition.
The combination of pentoxifylline and vitamin E has been shown to be effective in reversing
radiation fibrosis in this region. Many of these patients have had a benefit in pain response
in a time period of a few benefits. This study is a phase II study of these drugs for a 6
month trial period to assess the effect on chronic breast pain in breast cancer patients who
are 3 months to 3 years post radiation treatment.
Phase:
Phase 2
Details
Lead Sponsor:
University Health Network, Toronto
Collaborator:
Princess Margaret Hospital, Canada
Treatments:
alpha-Tocopherol Pentoxifylline Tocopherols Tocotrienols Vitamin E