The Use of Low Dose Metronidazole to Decrease Postoperative Pain After Endometriosis Surgery

• Status: Recruiting
• Trial end date: 2027-09-01
• Target enrollment: 0
• Participant gender: Female

Summary

The purpose of this study is to determine a difference in participant reported pain after endometriosis surgery in participants given oral metronidazole versus placebo.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Louisville
• Treatments: Metronidazole

Criteria

Inclusion Criteria:

• Able to give informed consent

• Women aged 18-50 years old

• Scheduled to undergo excision of endometriosis

• Able to read and write in English and or Spanish

• Pain score > 2 on a 10 point visual analogue scale at baseline

• Negative screening by CAGE questionnaire

Exclusion Criteria:

• Refusal to surgery

• Contraindication to surgery

• Known allergy to metronidazole

• Known allergy to any component in gelatin placebo capsules

• Scheduled hysterectomy

• Endometriosis excision surgery within the last 3 months

• Elevated serum creatinine

• Abnormal liver function test greater than 2 times the normal

• Current pregnancy

• Breastfeeding

• Use of Disulfiram within the last 2 weeks

• History of Cockayne syndrome

• Inability to abstain from alcohol during the use of study drug