The Use of Ketamine and Dexmedetomidine in Intensive Care Sedation

• Status: Recruiting
• Trial end date: 2021-12-30
• Target enrollment: 0
• Participant gender: All

Summary

The aim of the study is to compare the use of dexmedetomidine + ketamine with dexmedetomidine + placebo for sedation in ICU patients in terms of safety and efficacy

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Lebanese American University Medical Center
• Treatments: Dexmedetomidine; Ketamine

Criteria

Inclusion Criteria:

• Age between 18-80 years old

• Admitted to Intensive care unit at LAUMCRH

• Need for sedation for at least 24 hours

• Informed Consent Form signed by patient or surrogate

Exclusion Criteria:

• Pregnant patients

• At risk of increased intracranial pressure

• Aortic dissection

• Acute coronary syndrome

• Hypertension (SBP > 180 mmHg)

• Chronic alcoholism

• Acute alcohol intoxication

• Alcohol withdrawal

• Refractory status epilepticus

• History of psychiatric disorder

• Known allergy or contraindication to use of dexmedetomidine or ketamine

• Baseline hypotension (MAP<65 mmHg)

• Baseline bradycardia (HR<48 bpm)

• Patients receiving neuromuscular blocking agents

• Patients requiring deep sedation as determined by the ICU attending