The Use of Intra-articular Corticosteroid Injection to Treat Osteoarthritis of the Carpometacarpal Joint

• Status: Recruiting
• Trial end date: 2023-01-29
• Target enrollment: 0
• Participant gender: All

Summary

This randomized clinical trial (RCT) will evaluate 6-month outcomes following intra-articular injections for arthritis of the thumb carpometacarpal (CMC) joint by comparing corticosteroid plus local anesthetic versus saline (placebo) plus local anesthetic.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Shoulder & Upper Extremity Research Group of Edmonton; University of Alberta
• Treatments: Methylprednisolone; Methylprednisolone Acetate; Methylprednisolone Hemisuccinate; Prednisolone; Prednisolone acetate; Prednisolone hemisuccinate; Prednisolone phosphate

Criteria

Inclusion Criteria:

• Participants must be 40 years old or older at recruitment

• Present clinical and radiographic signs of thumb CMC OA using the American College of Rheumatology (ACR) criteria for the classification of hand osteoarthritis.

Exclusion Criteria:

• History of inflammatory arthritis

• Previous steroid joint injection to either thumb CMC joint

• Pregnancy or breastfeeding

• Psychiatric illness

• Cognitive impairment, or health conditions that preclude informed consent or receiving the injection

• People who do not speak/read/understand English, have no fixed address or contact, or are unwilling to complete follow-ups