The Use of Ceftaroline as Surgical Prophylaxis in Surgery With Risk of MRSA Infection
Status:
Unknown status
Trial end date:
2017-06-01
Target enrollment:
Participant gender:
Summary
The study is a randomized double-blinded study comparing ceftaroline to standard of care
therapy with cefazolin and vancomycin as surgical prophylaxis for high risk orthopedic and
cardiac surgeries. Study participants will be enrolled from those undergoing cardiothoracic
surgery involving sternotomy and those undergoing prosthetic joint replacement of either hip
or knee. Consenting patients will be randomized 2:1 to receive either ceftaroline or
cefazolin/vancomycin. This study will be blinded by the use of placebo vancomycin infusions
and placebo cephalosporin infusions. The primary end point will be the development of a
surgical site infection within 30 days of surgery.