The Use of Antimicrobial Agents in the Inhibition of Mutans Streptococci in Children With Dental Caries

• Status: Completed
• Trial end date: 2006-10-01
• Target enrollment: 0
• Participant gender: All

Summary

The aim of the present study was to compare salivary MS levels in four different groups of children with caries, that have been submitted to intraoral topical treatment with either 1,23% sodium fluoride, 1% chlorhexidine, 3% or 10% vancomycin, during 6 consecutive days. This clinical trial was designed to test two different hypotheses. First, that topical vancomycin would be more effective than chlorhexidine and sodium fluoride in salivary MS reduction. Secondly, a 6-day antimicrobial treatment with either one of these agents would produce a long lasting MS suppression, dispensing repeated antibacterial treatments.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Universidade Federal do Ceara
• Treatments: Chlorhexidine; Chlorhexidine gluconate; Fluorides; Listerine; Sodium Fluoride; Vancomycin

Criteria

Inclusion Criteria:

• Generally healthy children

• Children with at least one carious cavitated or non-cavitated lesion

• Must be able to spit

• Must be able to collaborate during clinical intervention

Exclusion Criteria:

• Children with history of allergies or allergic diseases, e.g. asthma, urticaria, rhinitis, sinusitis, or intra-oral soft tissue lesions

• Children who underwent antibiotic treatment during the course of this clinical trial

• Children with developmental disabilities

• Children with no clinical signs dental caries