The Use of A Prebiotic to Promote a Healthy Gut Microbiome in Pediatric Stem Cell Transplant Recipients
Status:
Recruiting
Trial end date:
2021-07-01
Target enrollment:
Participant gender:
Summary
Children enrolled in the study will receive either the prebiotic inulin or a placebo for 21
days during the study period. They will start taking the product seven days before transplant
starts until 14 days after transplant. Stool will be collected twice weekly until thirty days
after transplant or discharge, whichever occurs first. Stool samples will be sampled for
metagenomic sequencing to identify the diversity of bacteria within the stool. They will also
be analyzed for amount of short-chain fatty acid content (a breakdown product of inulin) as
well as for presence of genes that confer antibiotic resistance. From 30 days after
transplant until 100 days after transplant, two stool samples will be collected at regularly
scheduled follow up appointments (near day 60 and day 100). No product (inulin or placebo)
will be given during this time frame. The study period ends 100 days after transplant.
Phase:
N/A
Details
Lead Sponsor:
Ann & Robert H Lurie Children's Hospital of Chicago