Overview

The Treatment of Periodontal Diseases

Status:
Unknown status
Trial end date:
2016-10-01
Target enrollment:
0
Participant gender:
All
Summary
The purpose of this study is to examine if the correct use of antibiotics, as well as the application of one-day-treatment, in the therapy of periodontal diseases. The population of treated patients (184) are divided in 4 groups; Group 1: Metronidazole + mechanical treatment in one day, Group 2: Placebo + mechanical treatment in one day Group 3: Metronidazole + mechanical treatment on day 1 and 21 Group 4: Placebo + mechanical treatment on day 1 and 21 End points, BOP, Plaque, PPD, CAL, RAL, Microbiology will be recorded on all sites at 3 months, 1 -, 3 -, and 5 years post-treatment
Phase:
Phase 4
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
University of Oslo
Collaborator:
The Research Council of Norway
Treatments:
Metronidazole
Criteria
Inclusion Criteria:

- Females and males with advanced periodontal disease referred between November 2007 and
January 2009.

- No diseases known to be associated with periodontal diseases, i.e. diabetes mellitus,
rheumatoid arthritis, pregnancies.

- No continuous medication known to affect the severity or progression of periodontal
diseases.

- No previous systematic periodontal treatment.

- More than 5 pockets 5mm < PPD < 9 mm after a 3 month hygiene phase - i.e. before
inclusion into study.

- Oral hygiene; < 5% of surfaces with plaque at inclusion time.

- Signing an informed consent.

Exclusion criteria:

- diseases known to be associated with periodontal diseases, i.e. diabetes mellitus,
rheumatoid arthritis.

- pregnancy

- continuous medication known to affect the clinical expression of periodontal diseases

- subgingival microbiological diagnosis which reveals bacteria with reduced/no
sensitivity to metronidazole