The Treatment of 2 Chinese Medicines in Clozapine-induced Hypersalivation in Schizophrenia

• Status: Unknown status
• Trial end date: 2010-03-01
• Target enrollment: 0
• Participant gender: All

Summary

The goal of this research is hoping to combine traditional Chinese medicine medication and find out how to solve clozapine-induced hypersalivation, also reduce side-effect, medication compliance, improving life quality, improving social-function and reducing neopathy.

• Phase: Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Taichung Veterans General Hospital
• Treatments: Clozapine

Criteria

Inclusion Criteria:

1.20 year and older. All genders. 2.Psychiatry doctor diagnosed schizophrenia or schizoaffective disorder will be recruited for participation in this study.

3.Using clozapine as an antipsychotic drug and has a side-effect of hypersalivation.

4.Testee agree and sign informed consent forms to do this experiment.

Exclusion Criteria:

1. Use clozapine as an antipsychotic drug not over 8 weeks.

2. Testee have other diseases could influence saliva secretion, such as Parkinson's disease.

3. Pregnant, prepare to pregnant within half a year or in the lactation period.

4. Add or alter following medicines within 2 weeks:

4.1 Central acting 2-adrenergic receptor agonist 4.2 anticholinergic/antimuscarinic drugs 4.3 b-adrenoreceptor blockers, diphenhydramine, botulinum toxin injection

5. Testee's lever function test (AST/ALT) is higher than 3 (4 weeks medication).

6. Testee's kidney function test (Cr) is higher than 2.5mg/dl (4 weeks medication).

7. Testee have participate other medicine trial within one month.