The Therapeutical Role of Continuous Intra-femoral Artery Infusion of Urokinase on Diabetic Foot Ulcers
Status:
Unknown status
Trial end date:
2015-12-01
Target enrollment:
Participant gender:
Summary
- Diabetic foot ulcers (DFU) are one of the chronic consequences of diabetes which
constitute the most important cause of non-traumatic amputation of the inferior limbs.
Patients with diabetes are 22 times more likely to have foot ulceration or gangrene than
nondiabetics，while foot ulceration precedes 85% of lower-extremity amputation.
- Three factors combine to promote tissue necrosis in diabetic feet: ischemia, neuropathy
and trauma. Among them, ischemia peripheral arterial disease may play the important
roles in the development of DFU. Moreover, diffuse vascular disease is the main
characteristics, and thus it becomes difficult for treatment by using arterial bypass or
balloon angioplasty. Therefore, we hypothesized that continuous arterial thrombolysis
may be an effective therapy in diabetic foot. The purpose of this study is to
investigate the effectiveness and safety of continuous intra-femoral artery injection of
urokinase by micro-artery-pump in diabetic ulcers.