Mild thyroid failure is a common condition among older adults and has been associated with
numerous adverse effects on health, such as cardiovascular disease, cognition disturbances
and muscular problems. Mild thyroid failure has also been associated with an increased risk
of developing depression. To date, only few studies have investigated the effect of thyroid
hormone replacement on depression in patients with mild thyroid failure. This study therefore
aims to assess whether thyroid hormone replacement in older adults with mild thyroid failure
is associated with a decrease in the presence of depressive symptoms. This study forms a
substudy of a large international study on thyroid hormone replacement in older adults with
mild thyroid failure (the TRUST study).
Phase:
Phase 4
Details
Lead Sponsor:
University Hospital Inselspital, Berne
Collaborators:
Leiden University Medical Center University of Bern