The overarching goal of this project is to use [C-11]UCB-J to obtain spatial information on
neuronal synapse abundance and inform Alzheimer's disease (AD) progression. The investigators
propose to collect longitudinal amyloid, tau, and Synaptic vesicle glycoprotein 2A (SV2A)
positron emission tomography (PET) in participants in the Wisconsin Alzheimer's Disease
Research Center (ADRC) and Wisconsin Registry for Alzheimer's Prevention (WRAP) across the
clinical stages of AD, including cognitively unimpaired biomarker negative, unimpaired
biomarker positive, mild cognitive impairment (MCI), and dementia due to AD.