Overview

The Study of the Pathogenesis and Cognitive Behavioral Group Therapy in Obsessive-Compulsive Disorder

Status:
Completed
Trial end date:
2017-07-24
Target enrollment:
0
Participant gender:
All
Summary
This study intends to explore the pathogenesis of obsessive-compulsive disorder(OCD) by using biological technologies such as genetics and imaging, and to evaluate the efficacy of group cognitive behavioural therapy in OCD among the Chinese people. We also prepare to explore the synergistic effect of the pharmacological treatment combined with group cognitive behavioural therapy in OCD, and to find the biological and psychological index which can predict curative effect. This research includes case control study and randomized controlled single-blind study. At baseline, we compare the dimensions of clinical symptoms, genetics and imaging between OCD patients and healthy controls. The OCD patients are randomly assigned into pharmacological treatment, psychological treatment or pharmacological combined with psychological treatment for a 12-week treatment. After a 12-week treatment, the OCD patients will be divided into valid and invalid groups according to the results of our randomized controlled study by researchers: to our valid group, patients will continue the current treatment, and to the invalid psychological or pharmacological treatment group, patients will have a 12-week combined treatment. From the baseline, we will have a 9-month follow up for both OCD patients and healthy controls.
Phase:
N/A
Accepts Healthy Volunteers?
Accepts Healthy Volunteers
Details
Lead Sponsor:
Shanghai Mental Health Center
Treatments:
Fluvoxamine
Sertraline
Criteria
Inclusion Criteria:

- OCD patients: Among 18 to 54 years old, males or females; See a doctor because of OCD
recently,conform to DSM-Ⅳ(Diagnostic and Statistical Manual of Mental Disorders)
diagnostic criteria of OCD; The scores of the Yale-Brown Obsessive-Compulsive Scale
(Y-BOCS) is not less than 16 points; Has not yet accepted psychiatric medication or
have received irregular medication treatments and discontinuation for at least eight
weeks; A junior high school and above level of education; Has enough of seeing and
hearing level to complete the necessary checks; Right-handed (this standard is limited
to magnetic resonance imaging (MRI) detection); The Han nationality (this standard is
limited to genetic testing); Willing to participate in this study..

- Healthy controls: 1:1 match with the OCD group in age, gender and level of education;
Never appear symptoms of OCD, not comply with obsessive compulsive disorder, or other
mental disorders DSM-Ⅳ diagnostic criteria; There is no history of psychiatric
medication; No two lines three generations of history of mental disorder; Has enough
of seeing and hearing level to complete the necessary checks; Right-handed (this
standard is limited to magnetic resonance imaging (MRI) detection); The Han
nationality (this standard is limited to genetic testing); Willing to participate in
this study.

Exclusion Criteria:

- OCD patients: Conform to the DSM-Ⅳ other axis I except obsessive-compulsive disorder
diagnosis (M.I.N.I evaluation screening); Patients will not be able to complete the
required assessment check and cognitive behavioural therapy because of the severe OCD
symptoms; There is negative or a higher risk of suicide; Currently suffering from
serious physical disease or central nervous system disease, substance abuse; Pregnant
woman or woman who is ready to be pregnant, and lactating women; Used to have received
a full course of cognitive behavioral therapy, and no significant curative effect; In
presence of metallic implants: install pacemaker, intracranial silver clip, metal
false teeth, stents, artery clamp, joints, metal fixed, or other metal implants in
(this standard is limited to magnetic resonance imaging (MRI) detection).

- Healthy controls: There is negative or a higher risk of suicide; Currently suffering
from serious physical disease or central nervous system disease, substance abuse;
Pregnant woman or woman who is ready to be pregnant, and lactating women; In presence
of metallic implants: install pacemaker, intracranial silver clip, metal false teeth,
stents, artery clamp, joints, metal fixed, or other metal implants in (this standard
is limited to magnetic resonance imaging (MRI) detection).