The Study About Mechanism of Transcranial Magnetic Stimulation Treatment of Depression Using Medical Imaging
Status:
Recruiting
Trial end date:
2022-02-01
Target enrollment:
Participant gender:
Summary
Depression is the most common psychiatric condition and a important public health concern in
society. But medications for depression don't work as well as people expected and cause
serious side-effects. Transcranial magnetic stimulation (TMS) is a noninvasive electrical
stimulation treatment for depression, which has been approved by the FDA and added to the
Guidelines for the Treatment of Depression in China. Despite the effect of the treatment is
clear ,the TMS target,the neural circuit which plays a role in TMS and its mechanism remain
unknown now. TBS target and effective site may be not in the same position. A large number of
previous studies demonstrate the advantages and application prospects of different techniques
of magnetic resonance (MR)in the study of pathogenesis of depression. Based on the results of
previous research supported by the National Natural Science Foundation of China,the National
Key Technology Research and Development Program of China during the "10th Five-Year Plan" and
New Health Care and New technology. project team puts forward the idea of joint use of brain
structure imaging of MR ,Diffusion Tensor Imaging (DTI) and resting-state functional MRI
(fMRI) with different analysis methods to conduct a comprehensive study. The study is focused
on the effects of TBS treatment on brain structure network, fiber connectivity network and
functional connectivity network ,and nodes affected by it. Then we make further investigation
about the mechanism of TMS treatment. The research will provide not only help for studying
the pathogenesis of depression but also more reliable targets of next TMS treatment.
Phase:
Phase 1
Details
Lead Sponsor:
Health Science Center of Xi'an Jiaotong University Health Science Center of Xi’an Jiaotong University