The Statins on Glucose Homeostasis in Subjects With Impaired Fasting Glucose

• Status: Recruiting
• Trial end date: 2022-12-01
• Target enrollment: 0
• Participant gender: All

Summary

Evaluate the effects of rosuvastatin (maybe the highest diabetogenic) and pravastatin (seems to be protective) on the glucose homeostasis and other biomarkers in subjects with impaired fasting glucose.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Taipei Veterans General Hospital, Taiwan
• Treatments: Pravastatin; Rosuvastatin Calcium

Criteria

Inclusion Criteria:

1. Age 35-70 years old

2. Fasting blood glucose 100-125 mg/dL

Exclusion Criteria:

1. A1C >7.0%

2. 2hr glucose during OGTT >200 mg/dL

3. Total cholesterol >280 mg/dL

4. Previous diabetic history, coronary artery disease

5. Allergy to rosuvastatin or parvastatin

6. Baseline ALT more than 3 times UNL

7. Serum Cr > 2.0 mg/dL

8. Pregnancy, breast feeding or plan to be pregnant woman.