The Short-term Effects of Simvastatin on the Vision of Males Affected by Choroideremia

• Status: Terminated
• Trial end date: 2013-07-01
• Target enrollment: 0
• Participant gender: Male

Summary

Primary objective: To examine the short-term effects of of simvastatin on the vision on males with choroideremia, evaluated by full-field scotopic threshold testing. The investigators hypothesize that they will see a reversible decrease in the dark-adapted vision in participants taking simvastatin.

• Phase: Phase 1/Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Alberta
• Treatments: Simvastatin

Criteria

Inclusion Criteria:

• Participant is willing and able to give informed consent for participation in the study

• Male

• Diagnosed with choroideremia and in good health

• Willing to allow his general practitioner and consultant, if appropriate, to be notified of participation in the study

• Over age of 18 years

Exclusion Criteria:

• Female

• Significant health disease, disorder, or medication, which, in the opinion of the investigator, would put the patient at risk if he were to take simvastatin

• Already taking simvastatin or another statin