The Separate and Combined Effects of Oxytocin and Oxycodone on Decision-Making and Pain

• Status: Not yet recruiting
• Trial end date: 2022-10-01
• Target enrollment: 0
• Participant gender: All

Summary

Some research suggests that administration of oxytocin with oxycodone may reduce its abuse liability and improve its ability to reduce pain. In a 4-session laboratory study, the investigators will be evaluating the effects of oxycodone and oxytocin (combined and separately, across sessions) on experimentally-induced pain, subjective effects, decision-making, and activation of different neural substrates.

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Florida
• Treatments: Oxycodone; Oxytocin

Criteria

Inclusion Criteria:

• Individuals fluent in English will participate.

• Must report recreational use of opioids,

• be within 20% of their ideal body weight

• are not currently experiencing chronic pain (pain on most days during the past 3 months)

• have a systolic blood pressure of <=140 and diastolic blood pressure of <= 90, and a heart rate <= 90 beats per minute.

• Participants must also have a normal electrocardiogram (EKG) reading and bloodwork indicating no major health contraindications

Exclusion criteria:

• significant current physical disease or major psychiatric disorder

• no self-reported current interest in drug abuse treatment.

• Women who are pregnant or nursing.

• Any comorbid illicit substance use disorders or current clinically significant withdrawal for any abused drug excluding nicotine and caffeine.

• Any conditions that preclude safety in the MRI scanner, such as: implanted electrical devices (e.g., cardiac pacemaker, neurostimulator); implanted metallic clips or pins (e.g., aneurysm clip); a history of working with metal (unless able to demonstrate participant is MRI safe), and claustrophobia.