Overview

The Safety and Pharmacokinetics of Intraperitoneal Administration in Patients Undergoing Appendectomy for Uncomplicated Appendicitis

Status:
Completed

Trial end date:
2017-12-07

Target enrollment:

Participant gender:

Summary

The objective of this trial is to evaluate the safety of the intraperitoneal administration of the combination of fosfomycin, metronidazole, and granulocyte-macrophage colony-stimulating factor (GM-CSF) in patients undergoing surgery for uncomplicated appendicitis. Further, in a sub-trial the aim is to investigate the plasma concentrations of fosfomycin and metronidazole after intraperitoneal administration.

Phase:

Phase 2

Details

Lead Sponsor:

Herlev Hospital

Collaborators:

Barbara Juliane Holzknecht (Investigator)
Jacob Rosenberg (Sponsor)
Johan Juhl Weisser (Partner, data analysis)
Magnus Arpi (Investigator)

Treatments:

Fosfomycin
Metronidazole