The Safety and Efficacy of Recombinant Human Prolactin
Status:
Completed
Trial end date:
2011-03-01
Target enrollment:
Participant gender:
Summary
Medications used to increase breast milk production increase prolactin secretion, the main
hormone of lactation. There are no FDA approved medications used to improve breast feeding,
but metoclopramide is used off-label and can have intolerable side effects. We examined the
biological activity and safety of recombinant human prolactin (r-hPRL) as a potential
medication to augment lactation. In this study, the effect of r-hPRL on breast milk
production in women who did not recently deliver a baby and its effect on the bones and
menstrual cycle were tested.