The Safety and Efficacy of Epidural Oxycodone

• Status: Unknown status
• Trial end date: 2017-12-01
• Target enrollment: 0
• Participant gender: Female

Summary

There are conflicting results in earlier studies concerning the safety and efficacy of epidural oxycodone. In a study by Bäcklund and colleagues, epidural oxycodone was as effective as intravenous oxycodone, so they did not recommend epidural use of oxycodone. In another study, Yanagidate and Dohi reported that oxycodone was as effective in pain treatment with double dose compared to epidural morphine. In our previous study, epidural oxycodone provided safe and effective pain relief when compared to intravenous oxycodone.

In the present study, the aim was to compare the efficacy and safety of epidural or intravenous oxycodone in patients undergoing elective gynecological surgery with planned epidural pain treatment.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Kuopio University Hospital
• Collaborator: Admescope Ltd
• Treatments: Oxycodone

Criteria

Inclusion Criteria:

• Planned gynecological lower abdomen surgery with epidural pain treatment

• Informed consent obtained

Exclusion Criteria:

• Planned surgery under regional anesthesia

• contraindication to the study drug

• contraindication to the lumbar puncture

• Contraindication to oxycodone

• Pregnancy or lactation

• no informed consent