The Safety Evaluation of Drug Combinations Against High Altitude Pulmonary Hypertension
Status:
Completed
Trial end date:
2012-05-01
Target enrollment:
Participant gender:
Summary
This is a Phase I, three period, two sequence, open-label, randomized, crossover study, with
the primary objective of testing the safety and tolerability of combined oral doses of
theophylline and bambuterol in healthy human subjects. The secondary objective is to assess
the pharmacokinetic profiles of theophylline and bambuterol when administered alone or in
combination. It is hypothesized that the combination of these drugs is generally safe, and
that no drug interaction can be observed.