The Role of the Gut Microbiota in the Systemic Immune Response During Human Endotoxemia

• Status: Completed
• Trial end date: 2015-12-01
• Target enrollment: 0
• Participant gender: Male

Summary

The purpose of this study is to determine whether treatment with antibiotics, which harm the gut flora, causes the immune system to be less effective.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
• Treatments: Anti-Bacterial Agents; Antibiotics, Antitubercular; Ciprofloxacin; Metronidazole; Vancomycin

Criteria

Inclusion Criteria:

• Healthy

• Male between 18 and 35 years of age

• Capable of giving written informed consent

• Chemistry panel without any clinically relevant abnormality

• Normal defecation pattern

Exclusion Criteria:

• Major illness in the past 3 months or any chronic medical illness

• History of any type of malignancy

• Past or current gastrointestinal disease

• Known positive test for hepatitis C antibody, hepatitis B surface antigen or HIV antibody 1 or 2

• Current or chronic history of liver disease

• Subject uses tobacco products

• History, within 3 years, of drug abuse

• History of alcoholism

• Any clinically relevant abnormality on the 12-lead ECG

• The subject has received an investigational product within three months

• Use of prescription or non-prescription drugs

• Use of antibiotics within 12 months

• Known allergy to antibiotics

• Subject has difficultly in donating blood or accessibility of a vein in left or right arm.

• Subject has donated more than 350 mL of blood in last 3 months

• Difficulty swallowing pills

• Body mass index more than 28