The Role of Vasopressin Antagonism on Renal Sodium Handling

• Status: Completed
• Trial end date: 2015-02-01
• Target enrollment: 0
• Participant gender: All

Summary

Vasopressin has primarily been considered to be a water and osmosis regulating hormone that mediates its effects on renal aquaporin channels. Recent data suggest that vasopressin, through its V2 receptor, may also modulate sodium homeostasis. The purpose of this human physiology study was to test whether antagonism of the V2R alters urine sodium excretion in normal healthy volunteers.

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Brigham and Women's Hospital
• Collaborator: Otsuka Pharmaceutical Co., Ltd.
• Treatments: Arginine Vasopressin; Tolvaptan; Vasopressins

Criteria

Inclusion Criteria:

• - Blood pressure <130/85 mmHg and >100/50 mmHg

• Normal laboratory values for (see "Normal Values" table):

• Complete blood count

• Serum creatinine, sodium, potassium, glucose, liver enzymes

• Urinalysis

• ECG

Exclusion Criteria:

• - Alcohol intake >12 oz per week

• Tobacco or recreational drug use

• History of coronary disease, diabetes, hypertension, stroke, kidney disease, or illness requiring overnight hospitalization in the past 6 months

• Any prescription medication or herbal medication use except oral contraceptive or multivitamin

• Pregnancy or current breastfeeding

• First degree relative with hypertension, diabetes, stroke, renal or cardiac disease