The Role of Substance P on Perception of Breathlessness During Resistive Load Breathing
Status:
Completed
Trial end date:
2013-03-01
Target enrollment:
Participant gender:
Summary
Substance P is released from sensory nerves and transmits pain information into the central
nervous system. As pain and dyspnea share many characteristics, including similar
neurological pathways, it is possible that substance P may contribute to the sensation of
dyspnea. The hypothesis of the study is that patients with chronic obstructive pulmonary
disease (COPD) will provide lower ratings of breathlessness during resistive load breathing
with oral aprepitant, a medication that blocks the activity of substance P, compared with
placebo.