The Role of Serotonin in Compulsive Behavior in Humans: Underlying Brain Mechanisms
Status:
Recruiting
Trial end date:
2024-08-01
Target enrollment:
Participant gender:
Summary
The aim of this project is to investigate:
- The status of the central serotonin (5-hydroxytryptamine, 5-HT) system in compulsive
behaviour and how it is affected by sub-chronic escitalopram administration
- The mechanisms underlying how sub-chronic administration of escitalopram affects the
central 5-HT system
- How changes in cognitive performance, including the balance between habitual and
goal-directed mechanisms, are affected in compulsive behaviour by boosting 5-HT function
- How functional brain changes in cognitive function measured with magnetic resonance
imaging relate to altered 5-HT function following escitalopram administration.