The Role of Secretin on the Energy Homeostasis

• Status: Completed
• Trial end date: 2020-09-29
• Target enrollment: 0
• Participant gender: Male

Summary

As of last year, new insight into the function of secretin was brought about as rodent studies showed secretin to possess potential body weight-regulating effects. In these studies, secretin was shown to increase non-shivering thermogenesis in brown adipose tissue (BAT), decrease meal size and promote meal discontinuation. The mechanisms behind these regulatory effect of secretin on energy homeostasis are unclear,

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Steno Diabetes Center Copenhagen
• Treatments: Secretin

Criteria

Inclusion Criteria:

• Age between 18 and 75 years

• Body mass index between 18.5 and 27.5 kg/m2

• Informed consent

• Body weight above 50 kg

Exclusion Criteria:

• Anaemia (blood haemoglobin below normal range)

• Known liver disease and/or alanine aminotransferase and/or aspartate transaminase > 2 times upper normal values

• Nephropathy (serum creatinine above normal range and/or albuminuria)

• Clinically significant kidney function impairment or other laboratory findings leading to the diagnosis of clinically relevant disorders (thyroid dysfunction, anaemia etc)

• Any physical or psychological condition that the investigators feel would interfere with trial participation