The Role of S-nitrosohemoglobin in Regulating Systemic Blood Flow During Hypoxia and Normoxia
Status:
Terminated
Trial end date:
2013-08-01
Target enrollment:
Participant gender:
Summary
Nitric oxide is believed to contribute to regulation of blood flow by its selective binding
to circulating hemoglobin (forming S-nitrosohemoglobin, SNO-Hb) and release in a
PO2-dependent manner. This study is designed to test that hypothesis by measuring the effect
of hypoxia and exercise on forearm blood flow before and after depletion of SNO-Hb using oral
N-acetylcysteine.